Gas, abdominal pain, diarrhea. May cause Vitamin-B12 deficiency with long use. Fewer side effects with ER/XR extended release form. Fear it causes lactic acidosis is not supported by high quality research. Can cause a lowering of testosterone in men and women.
66% more heart attacks. Causes water retention. Causes weight gain. Causes heart failure. Causes osteoporosis. Causes macular edema
From Prescribing Information: "In postmarketing experience with ACTOS, cases of congestive heart failure have been reported in patients both with and without previously known heart disease....In postmarketing experience with ACTOS, reports of hepatitis and of hepatic enzyme elevations to 3 or more times the upper limit of normal have been received. Very rarely, these reports have involved hepatic failure with and without fatal outcome"Macular edema. Weight gain. Ovulation in premenopausal women. Raises LDL
Can cause hypos. Causes hunger and weight gain May cause reversible beta cell burnout with prolonged use. Least heart attack risk of this class of drugs
Amaryl (glimepiride), Glyburide, (Glucovance is glyburide with added metformin) Glucatrol, Diabeta (glipizide):
Stimulate receptors on heart tissue leading to higher rate of heart attacks
Can cause hypos. Same dose much more powerful when combined with metformin. Causes weight gain. Changes concentration of many other drugs including birth control pills in the bloodstream. May cause upper respiratory infection, back pain, flu symptoms, dizziness, joint problems.
Increases stroke and heart attack when started, raises risk of acute kidney injury, causes dangerously low blood pressure, low potassium. Too new for other side effects to be apparent.
Causes growth of abnormal alpha and beta cells in pancreas growing a huge mass of abnormal cells that is associated with the growth of precancerous pancreatic adenomas (tumors). Vomiting. Nausea. Chills. Headache. Weakness. Blood pressure fluctuations. Tooth pain. Constipation. Nasal congestion. Doubles risk of pancreatitis.
Label contains Black Box warning "Liraglutide injection may increase the risk that you will develop tumors of the thyroid gland, including medullary thyroid carcinoma (MTC; a type of thyroid cancer), which may cause death if it is not treated at an early stage." Likely to also cause the abnormal cell overgrowth associated with all incretin drugs that leads to the growth of precancerous adenomas (tumors).May cause renal [kidney] impairment. Study shows it causes more serious rashes than Byetta. Vomiting. Nausea. Chills. Headache. Weakness. Blood pressure fluctuations. Tooth pain. Constipation. Nasal congestion. Doubles risk of pancreatitis.
Label warns it may cause pancreatitis, acute renal (kidney) failure, and severe allergic reactions including severe skin rashes. Research found it doubles risk of pancreatitis. Causes strikingly abnormal cell overgrowth in the pancreas and microadenomas (benign glandular tumors that can become cancerous) and neuroendocrine tumors.Cold symptoms, inflamed sinuses, raised blood pressure,constipation. Elevated leucocyte count. DPP-4 inhibition has been called "trigger for prostate cancer", also associated with metastasis in ovarian and lung cancers and melanoma.
Label warns these drugs may cause acute pancreatitis, severe allergic reactions. Research found it doubles risk of pancreatitis. Very likely to cause strikingly abnormal cell growth in pancreas and microadenomas (benign glandular tumors that can become cancerous) and neuroendocrine tumors as this appears to be a class effect found in all incretin drugs. Commonly causes cold symptoms, inflamed sinuses, raised blood pressure,constipation. Lowers lymphocytes, sometimes dangerously.Concentration rises with grapefruit juice, ketoconazole, erythromycin, and verapamil. Raises peak concentrations of sulfonylureas, Actos and Avandia causing hypos.DPP-4 inhibition has been called "trigger for prostate cancer", also associated with metastasis in ovarian and lung cancers and melanoma.
For more information about how to control glucose with minimum medication: